The development of cross-sectional and bronchoscopic technique making advantage of optical and ultrasound imaging technology as well as therapeutic interventional options has had considerable impact on the management of pulmonary diseases. While interventional pulmonology is mainly limited to the central half of the tracheobronchial system, CT (computed tomography) and MRI (magnetic resonance imaging) are limited much less. However, cross-sectional imaging provides information distally to a stenosis, for example, the relation of a lesion to the adjacent anatomy, and allows for detailed evaluation of the parenchyma. This includes the whole lung from the apex to bases with the option to change a virtual point of view in any direction, while bronchoscopy is limited to a certain point of view. Furthermore, CT and MRI provide the possibility for functional judgment of parenchyma and bronchi in terms of perfusion, ventilation, collapsibility, and others, while endoscopy is capable for real-time imaging during continuous respiration including the option for manipulation, biopsy, and even treatment. A wide range of synergies of radiological and advanced interventional endoscopic procedures in patients with both central and peripheral airway disease is the result of this concept.