Emphysema with hyperinflation is associated with significant shortness of breath, limited exercise capacity, and worsened quality of life. Hyperinflation is associated with neuromechanical dissociation and increased ventilatory effort leading to strategies to target volume reduction. Lung volume reduction surgery to remove the most diseased nonfunctioning lobe has been associated with improved outcomes. However, due to the perioperative risk associated with surgery in selected patients and the lack of efficacy and safety concerns in homogeneous disease, bronchoscopic methods of lung volume reduction have been explored. The three bronchoscopic approaches include causing atelectasis of the diseased lobe using endobronchial devices, sclerosing the disease lobe using sclerosing therapies, and improving deflation of the lobe using airway stents. Here we discuss the mechanism of action, clinical evidence, patient selection, and method of delivery of multiple bronchoscopic techniques including endobronchial valves, endobronchial coils, bronchoscopic thermal vapor ablation, and airway stents.