This chapter explores the challenges and opportunities of research-oriented Campus as a Living Lab programs. Over the last decade, universities have recognized the benefits of using the campus as a “living lab” for experiential learning. However, extending the living lab concept to faculty and professional researchers is rare. This chapter explores research-oriented Living Lab programs as a positive means for supporting the start-up eco-system, providing the infrastructure for proof-of-concept testing, and filling a critical gap in the innovation pathway. It also identifies the key reasons why these kinds of programs are difficult to facilitate at the staff level. The conclusion is that designing such a program requires a coordination team that can address barriers—like authorization, space allocation, and internal policies or regulations—and can serve as the coordination link among administrative and operational units. It is also clear that the coordination team must take the lead in risk management and ensuring compliance with health and safety requirements and data privacy regulations.