In this chapter, we outline an approach to the initial dosing and selection of medical cannabis formulations for different groups of patients. There are currently no disease-specific dosing recommendations, so a patient-specific approach to dosing is the current practice. The overwhelming variety of medical cannabis formulations and their effects are defined for quick reference. An outline for dosing, titration, monitoring, and discontinuation is provided for cannabis-naive patients, experienced patients, and patients with severe symptoms. Considerations about drug interactions, monitoring, and adverse effects are also provided.