The chapter examines the governance structures of the EU-Caribbean inter-regional governance relationship. The actors, processes, and major issue areas are addressed. The Caribbean has had a long-standing relationship with the EU dating back to Lome I in 1975. Their engagement has been mainly conducted via CARIFORUM in the framework of the African, Caribbean, and Pacific (ACP) group of states, now the OACPS. EU efforts to engage with the Caribbean within the LAC framework began in the 1990s but gained traction only after 2011, following the establishment of CELAC and the subsequent EU–CELAC Strategic Partnership. Primary documents, secondary texts, and expert interviews were utilized to execute the research and analysis. The findings suggest that the LAC framework is not yet integral to the Caribbean’s engagement with the EU. The relationship is asymmetrical but has yielded benefits to both sides. The chapter concludes that governance institutions and processes need to be re-engineered and revitalized to retain relevance, legitimacy, and strategic value for the parties.