The area of geographic information system (GIS) is attracting growing attention because geographic data are now everywhere, in this work with electronic health records. Few studies have explored avoidable diabetes-related hospitalizations in Mexico, and there is no systematic process. This paper provides a spatio-temporal analysis through calculating age adjusted rates by sex and geographical area. This study aims to determine the rates of avoidable hospitalizations as a metric to assess the quality of primary diabetes care prevention, stratifying the country in eight geographical areas. We followed the method used in epidemiology and the approach is mainly based on biostatistics techniques and the GIS process. These results emphasize the importance of working together between GIS experts and epidemiologists. The data presented here reveal that the geographic area with the highest rate of avoidable diabetes-related hospitalizations is the peninsula of Mexico. These findings add substantially to our understanding of how diabetes is cared for and decision makers can generate public health policies and improve health care systems.