The swift spike in electronic waste (e-waste) in modern society urges for novel sustainable management methods. Worldwide microbial-aided nanobiotechnology is now considered as a potential key for managing e-waste and promoting environmental sustainability. This approach harnesses microbial consortia and nanomaterials to remediate, recycle, and recover e-waste. The chapter shows that microbial-aided nanobiotechnology could potentially break down and detoxify various e-waste materials, reducing environmental pollution and resource depletion. Microbial processes utilizing nanomaterial platforms could concentrate on recovering important metals and components from electronic gadgets, supporting circular economy principles and resource conservation. Its potential is intriguing, but scalability, cost-effectiveness, and technical optimization need further research. Bioreactor design, novel microbial strains, and microorganism-nanomaterial synergy are potential research areas awaiting to be delved into. Academic, industrial, and regulatory collaboration is needed to successfully use microbial-aided nanobiotechnology in e-waste disposal. Safe and sustainable worldwide deployment of these technologies needs strong legislative frameworks and regulatory norms. This chapter meticulously highlights the pivotal role of microbial nanotechnology in optimizing treatment methods for maximum efficiency and sustainability. It aims to showcase the synergistic effects of integrating microbiology and nanotechnology for sustainable treatment, scientifically illustrating how microbial nanobiocomposites amplify efficiency in e-waste recycling processes through enhanced eco-friendly material recovery.