In order to summarize the application of several representative boundary identification methods in the regional gravity survey in Jiuquan-Wuwei area, this paper first introduces the basic principles of horizontal first-order derivative and vertical second-order derivative, and then uses these two methods to calculate Bouguer gravity anomaly values in the work area. On the basis of the calculation results, 26 faults are identified and 90 local gravity anomaly boundaries are compared. Based on the analysis of the characteristics of faults and local anomalies, the following conclusions are drawn: the faults in the work area are generally manifested as NE faults represented by Yabulai fault and NW faults represented by Longshoushan fault; The local gravity anomaly in the work area is mainly caused by basement uplift and basement depression.