The impacts of draining wetlands on the ecohydrology of a region have been observed in many parts of the world. Wetlands are known to sequester carbon through their productive environment where wetland vegetation abundantly grows, and organic matter accretes as peat or muck soil. The draining of wetlands reverses ages of carbon sequestration to immediate carbon release into the atmosphere defeating the global initiative of managing global warming emissions. The carbon credit value of the wetlands is important. Wetlands serve as flood storage and wildlife habitat. Wetlands store incoming solar energy and use most of it as latent heat (evapotranspiration) with cooling effect more than sensible heat that raises the surrounding temperature. If drained, the change in fractionation of solar energy in favor of sensible heat will affect the regional rain machine and warmer and drier environments will be frequent. Drainage of wetlands exposes the peat soil for soil oxidation and peat fire during drought releasing carbon to the atmosphere and nutrients and metals to the surrounding water body. Fire and oxidation result in significant topographic change through subsidence and hydraulics changes of the affected areas. The drainage of the Everglades wetlands in the USA has shown impacts of draining regional wetlands on the regional hydrology and environment and the cost of flood control. The Everglades experience will help predict the outcomes of other wetlands drainage such as the Sudd marshes in the Nile basin.