The genusGenus Salvia belongs to the Lamiaceae family and includes about 1000 speciesSpecies and Salvia officinalisSalvia officinalis is the type speciesSpecies of the genusGenus. Currently, S. officinalis is divided into five subspeciesSubspecies and the Balkan and Mediterranean areas are the center of differentiation. Local populations and spontaneous hybridizationsHybridization with other similar speciesSpecies have contributed to the creation of the cultivatedCultivated varietiesVariety . S. officinalis is a multifunctional plant because it is used in various fields, therefore the different accessions and cultivarsCultivars on the marketMarket differ according to their use: food, ornamentalOrnamental, pharmaceutical, herbal and perfume fields. Most of the studies focus on the productionProduction of the essential oilsEssential oils produced by the glandular trichomes of the plant and on the productionProduction of secondary compounds present in flowersFlower, leavesLeaf and roots. Traditionally, S. officinalis is propagated by seedSeed or cutting and cultivatedCultivated in the field for the productionProduction of extractive biomass, and its cultivationCultivation requires low inputs. The productionProduction of secondary compounds is subject to variations due to environmental conditions, cultural techniques and extraction systems. However, in recent decades, in vitro micropropagationMicropropagation, in addition to allowing the cloning of selected genotypesGenotype, has opened up the possibility of producing sage secondary compounds using various biotechnological tools. Traditional breedingTraditional breeding methods use wildWild populations and cultivarsCultivars and focus on the productionProduction of secondary compounds and toleranceTolerance to certain environmental conditions. The activityActivity of molecular marker assisted breedingMolecular marker assisted breeding in S. officinalis is starting and many molecular markersMolecular markers have already been developed.