Nanofertilizers are a novel product that can benefit soilless agricultural systems also, such as hydroponics, aeroponics and aquaponics. These fertilizers at the nanoscale level improve the efficiency of nutrients, decrease the adverse effects on the environment and sustainably support the production of crops. This study investigates the impact of nanofertilizers on soilless agricultural systems, specifically examining their mechanisms of action, advantages, difficulties and potential for future development. Through analyzing up-to-date research and case studies, our objective is to thoroughly comprehend the potential of nanofertilizers in transforming soilless farming. These fertilizers can enhance plant growth, nutrient absorption, and crop yield, significantly contributing to contemporary agriculture sustainability.