The presentation “Data-Driven Strategies for Enhancing Supply Chain and Transportation Infrastructure Resilience” underscores the crucial role of data-driven approaches and Key Performance Indicators (KPIs) in fortifying supply chains and transportation infrastructure. It emphasizes the importance of monitoring socio-economic factors and implementing resilience measures to address the complex impacts of disruptions. KPIs such as on-time delivery, inventory turnover, and capacity utilization play a pivotal role in assessing and improving resilience, ensuring business continuity, economic stability, and community well-being. The presentation is structured around a comprehensive framework, including an in-depth analysis of supply chain and transportation infrastructure resilience, highlighting the significance of integrating socio-economic indicators and supply chain KPIs. Through case studies, the methodology section demonstrates the practical application of these data-driven strategies, offering valuable insights and recommendations for enhancing resilience. The conclusion succinctly summarizes key findings their implications for business and policy, and outlines future research directions.