This chapter explores the transformative potential of integrated Game-Based Learning (GBL) and interdisciplinary educational strategies to address the multifaceted challenges of the Anthropocene. It begins by identifying the limitations of traditional academic disciplines in preparing individuals for the complexities of the modern world and highlights the urgent need for innovative paradigms that can promote the development of adaptive critical thinking. Game-based integrated learning is presented as a comprehensive approach that crosses disciplinary boundaries and develops various skills such as critical thinking, collaboration and adaptability. Students are encouraged to solve problems, make informed decisions and observe the consequences of their actions, increasing engagement and motivation. This chapter also advocates interdisciplinary educational strategies that integrate project-based, experiential-based and community-based learning to develop a deep understanding of issues related to the Anthropocene. Despite technological barriers, access and equity issues, and assessment challenges, there is consensus about the transformative power of GBL when implemented effectively. It also highlights the important role of teachers in integrating GBL into their teaching practices and the importance of comprehensive educational programmes and ongoing support. As we move beyond education in the Anthropocene, GBL will become a beacon of innovation, preparing students to tackle complex real-world challenges with curiosity, adaptability, determination and in a changing world. You will become more resilient.