Electronic waste or e-waste is one of the rapidly growing environmental problems of the world. Recent statistics showed that there will be an increased need for various renewal substances for manufacturing machinery and automobiles, medicines, items for the construction industry, and many more industries. This calls for more efficient solutions to manage e-waste. E-waste has both toxic and valuable materials. Printed circuit boards (PCBs) are the most complex, hazardous, and valuable components of e-waste. Through the utilization of indigenous microorganisms, e-waste can be recycled and leading to avenues such as for wealth generation. Biological methods like bioleaching are used commonly because it is cost-efficient and environmentally friendly. Bioleaching also offers diverse ways to extract metals from the printed circuit board. This chapter presents a new paradigm for e-waste management, emphasizing the importance of indigenous microorganisms in wealth creation and environmental sustainability.