This chapter examines the role of strategic design within industry and business, emphasising its transformative impact on economic, technological, and human dimensions. It traces the evolution of strategy and design through industrialisation to the modern day, where design addresses complex organisational challenges. The chapter highlights crucial concepts such as design thinking, the integration of design and management, and the pivotal role of technological innovation. It discusses strategic design’s contributions to fostering innovation, sustainability, and competitive advantage in organisational design. Through case studies, the chapter illustrates strategic design’s practical applications, referencing Galbraith’s Star Model™ as a framework for implementing strategies within organisations. These case studies showcase strategic design as an essential tool for navigating contemporary challenges, advocating a holistic, user-centred approach that merges creativity, strategy, technology, and human considerations in organisational systems. The cases range from digital transformation in a high-tech firm and developing employee-centric green pension funds, to coaching employees for upcoming transformations, and testing sustainable living solutions with advanced monitoring, emphasising strategic goals, user involvement, and systems thinking.