This chapter examines Coleridge’s Theory of Life in the context of a dispute in British medical institutions concerning the scientific status of comparative anatomy. It argues that Theory of Life is centered on the provocation that comparative anatomy is properly organized under the idea of life. It then demonstrates how Coleridge’s method for a comparative science impacted several key figures in British bioscience, including Joseph Henry Green, William Whewell, and Richard Owen. It concludes that Coleridge’s ability to adopt, transform and apply the insights of German physiology to the scientific debates in London’s intellectual circles played a greater role the development of comparative anatomy in Britain than has previously been recognized.