This chapter, grounded in the Configurational Theory, introduces a model for high-performing small and medium-sized enterprises (SMEs) to effectively address the new environmental challenges in traditional manufacturing Global Value Chains (GVCs). Based on a sample of 240 manufacturing companies, our model emphasizes five key strategic development axes: customization of products and services to meet diverse customer needs; commitment to sustainability through eco-friendly practices; forging strategic partnerships for ongoing knowledge acquisition and innovation; adopting blended manufacturing strategies that balance local and international production for optimal flexibility; and enhancing international commitment by improving distribution channels and market reach. This integrated model serves as both a foundation for systematic empirical investigation and a practical guide for managerial practice. Its dynamic and comprehensive approach provides valuable insights for policymakers and industry stakeholders, aiming to support the growth and development of SMEs in the manufacturing sector amidst evolving global challenges.