Pharmacophores are abstract descriptions of the properties of drug-like molecules that are necessary to understand how they interact with their biological target and hence, characterize their medical action. Mastering pharmacophores is essential for pharmaceutical science but this concept is very hard to grasp. This is mainly due to the difficulty of perceiving the three-dimensional aspect of pharmacophore models but also their combinatorial nature. We therefore designed Escape from PharmaZ, a hybrid serious game for undergraduate students. It is composed of a collaborative board game and a dedicated Augmented Reality (AR) smartphone application that allows the students to visualize and manipulate 3D molecular structures. The preliminary tests of this game, with 24 volunteers, show that it helps understand the pharmacophore concept, especially for novices in chemistry. The results also show that the game mechanics and the AR rendering help players better understand the nature of pharmacophore features and the importance of their spatial and combinatorial positioning.