Abdominal compartment syndrome (ACS) is similar to other compartment syndromes in that it occurs when the pressure inside a closed compartment (i.e., the abdomen) becomes elevated and impacts the normal function of the contents of that compartment, leading to decreased oxygenation and perfusion. ACS is defined as a sustained intra-abdominal pressure (IAP) >20 mmHg that is associated with new organ dysfunction/failure. Intra-abdominal hypertension (IAH) is defined as IAP ≥12 mmHg. Ruptured abdominal aortic aneurysm (AAA), major pancreatic injury, burns, trauma, and significant bowel injury are examples of clinical scenarios that require large volume fluid resuscitation and put patients at risk for ACS. Other risk factors include increased intra-abdominal pressure due to ascites, pregnancy, abdominal packing for hemorrhage control, bowel distention secondary to obstruction, and intra-abdominal masses.