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• Diffuse growth pattern, loss of cellular adhesion  • Single file patterns of cells  • Not E-cadherin  • 15% of breast cancers  • Not always palpable mass  • High false negative rate with mammograms and ultrasounds  • ALH (atypical lobular hyperplasia) gives you 4–5× risk of breast cancer  • LCIS (lobular carcinoma in situ) 8–10× risk of developing breast cancer  • Luminal usually (estrogen and progesterone positive)

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Invasive Lobular Breast Cancer

  • 章节

  • 发表日期：

    2025年

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  • Michele Fantazzio

摘要

• Diffuse growth pattern, loss of cellular adhesion  • Single file patterns of cells  • Not E-cadherin  • 15% of breast cancers  • Not always palpable mass  • High false negative rate with mammograms and ultrasounds  • ALH (atypical lobular hyperplasia) gives you 4–5× risk of breast cancer  • LCIS (lobular carcinoma in situ) 8–10× risk of developing breast cancer  • Luminal usually (estrogen and progesterone positive)