Sexually transmitted intestinal infections primarily affect populations engaging in practices such as anal intercourse. Key pathogens include Chlamydia trachomatis, Neisseria gonorrhoeae, and various enteric bacteria like Shigella and Salmonella. Symptoms can range from mild proctitis to severe dysentery, characterized by abdominal pain, diarrhea, fever, and rectal bleeding. Diagnosis typically involves stool culture, serological tests, and clinical evaluations. Treatment is pathogen-specific, often consisting of antibiotics and supportive care. Preventative measures include safe sexual practices, education, and timely screening. The epidemiology of these infections highlights their higher prevalence among men who have sex with men (MSM), although they can also impact heterosexual populations. Public health initiatives aimed at increasing awareness and improving sanitation are essential to reduce gastrointestinal infections.