The chapter explores the innovative use of citrus waste in the development of advanced delivery systems for drugs and nutraceuticals. Citrus waste, a substantial byproduct of the citrus industry, is repurposed for its unique properties in enhancing the delivery and efficacy of pharmaceutical and nutraceutical compounds. The research investigates the feasibility of utilizing citrus waste components, such as peels and extracts, to create effective drug delivery systems. This involves examining the bioactive compounds present in citrus waste, including polyphenols and essential oils, and understanding their potential in controlled release mechanisms. The chapter likely delves into various formulation techniques and technologies employed to harness the therapeutic benefits of citrus waste. This may include encapsulation methods, nano-carriers, and other innovative delivery approaches. Furthermore, the exploration of the sustained release of nutraceuticals from citrus waste-derived matrices may contribute to advancements in preventive healthcare. Through a comprehensive review of existing studies and emerging research, the chapter aims to elucidate the role of citrus waste in the pharmaceutical and nutraceutical industries, highlighting its potential to revolutionize drug and nutrient delivery systems. The innovative utilization of citrus waste not only addresses sustainable waste management but also opens new avenues for improving the effectiveness and bioavailability of therapeutic and nutritional compounds.