Valorizing citrus processing waste is a critical theme to enhance sustainability within the citrus industry nowadays. This chapter explores innovative strategies for valorizing citrus processing waste, aiming to mitigate environmental impacts while creating economic value. Citrus waste, encompassing peels, seeds, and pulps, poses significant environmental challenges when not effectively utilized. The focus is on extracting valuable components like bioactive compounds, essential oils, and dietary fibers, thereby transforming waste into high-value by-products. Use of a comprehensive exploration of innovative methodologies such as advanced extraction processes, enzymatic treatments, and biotechnological approaches aims to unlock the latent potential of citrus waste. By adopting a circular economy framework, the chapter underscores the economic and environmental advantages of repurposing citrus waste in diverse industries, including pharmaceuticals and food. Offering practical insights, this chapter contributes to the evolving discourse on sustainable waste management, providing a roadmap for industry practitioners, policymakers, and researchers seeking to optimize resources and minimize environmental impact in the citrus processing sector. Overall, this chapter underscores the importance of valorizing citrus processing waste as a sustainable approach to address environmental concerns, enhance resource efficiency, and promote economic viability within the citrus industry and beyond.