Citrus fruits are widely consumed worldwide for their refreshing flavor and nutritional benefits. However, the processing of citrus fruits generates a substantial amount of waste, including peels, seeds, and pulp, which are often discarded as byproducts. In recent years, there has been growing interest in exploring the potential of citrus waste as a source of bioactive compounds with nutraceutical properties. This review provides an overview of nutraceuticals derived from citrus waste, focusing on their bioactive components, health benefits, and potential applications in functional foods and dietary supplements. Citrus waste contains bioactive compounds which exhibit a range of health-promoting properties, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and cholesterol-lowering effects. The consumption of citrus waste-derived nutraceuticals has been associated with numerous health benefits. Incorporating these bioactive compounds into food and supplement formulations not only enhances their nutritional value but also provides consumers with natural alternatives to synthetic additives and preservatives. The extraction and utilization of these bioactive compounds from citrus waste offer valuable opportunities for waste valorization, resource recovery, and value-added product development in the food, pharmaceutical, and cosmetic industries. Nutraceuticals derived from citrus waste offer promising prospects for promoting human health, supporting sustainable development, and driving innovation in the food and nutrition industry.