As evidence guides practice, it is essential for navigation programs to identify core metrics and standardize data collection to demonstrate program outcomes. There is a discontinuity in the literature regarding the key areas that measure the success of navigation programs: patient experience (PE), clinical outcomes (CO), and business performance or return on investment (ROI) metrics. The National Quality Forum’s criteria for measure development designed a solid framework with four pillars: essential to measure and report, scientifically acceptable, usable/relevant, and feasible to collect. The Academy of Oncology Nurse & Patient Navigators (AONN+) Metrics Task Force developed standard metrics using scientific methodology in PE, CO, and ROI using the AONN+ domains for certification. These domains contain a comprehensive list of all areas navigators practice to provide their organizations with quality patient care and financial stability. The 35 developed metrics are baseline metrics that all navigation programs should be evaluated and monitored, no matter their structure. The AONN+ Metrics also support the core competencies of the national organizations: George Washington Cancer Center, Oncology Nursing Society, Professional Oncology Navigation Taskforce, and the American Cancer Society National Navigation Roundtable. Navigation programs are developing at different rates within diverse structural organizations and settings, which will determine which standardized metrics are essential to measuring outcomes for their specific navigation program. The AONN+, Metric IRB, and the Implementation Toolkit guide the standardized metrics. The metrics align with national standards such as the Commission on Cancer (CoC), National Accreditation Program for Breast Centers (NAPBC), Quality Oncology Practice Initiative (QOPI), value-based care, and, recently, the 2024 CMS reimbursement for principal illness navigation. National standards help drive continuous quality improvement and value and identify best practice programs that elevate cancer care on a grander scale. Integrating performance improvement methodologies and data analytics drives quality outcomes and reimbursement.