This chapter provides a comprehensive guide for African managers seeking to understand the sustainability and resilience factors in responsible innovation projects. This chapter emphasizes the relevance of project management standards, African management practices, and the unique African context, offering an opportunity to improve protocols for managing resilience and sustainability in innovation projects. The chapter has four key objectives: to document responsible innovation, resilience, and sustainability in project management; to identify factors that facilitate or hinder these elements; and to model these factors in the African context. The study includes three subgroups of participants: project leaders in renewable energy, agropastoralism, and agribusiness in Chad; managers of 188 innovation projects applying African management practices and ISO standards; and key stakeholders in organizations funding responsible innovation projects. Using a mixed-methods approach, the research deconstructs the innovation project cycle from design to implementation. The findings reveal that African management practices promote sustainability and resilience at the design stage, while ISO standards are key drivers during implementation. The integration of both factors enhances the sustainability and resilience of responsible innovation projects. This chapter is valuable for researchers and project managers, offering new insights and variables for strengthening project outcomes in the African context.