This paper influences a study of thermally and chemically reactant Williamson nanofluid with viscous dissipation, Joules heating, and magnetic field across an exponential stretching sheet. The impacts on velocity, temperature, and chemical reaction parameters were simulated by using a bvp4c solver in MATLAB. The governing equations in partial differential equation (PDE) are expressed into an exact ordinary differential equation (ODE) with the similarity transformations. The graphical results of parameters skin friction, Sherwood numbers, and Nusselt numbers are exhibited and their results are tabulated. The impact of thermally and chemically reactive Williamson nanofluid, magnetic fields, and Joule’s heating on mass gradient, velocity, and temperature for different components is examined in this work.