“All cells inside a human being swim in a surrounding fluid”. This is the first line of the “Vademecum Lymphologicum”, intended to guide you through the fascinating science and sometimes challenging everyday life of lymphology. What’s next? What development will scientific lymphology undergo in the future, and how will this change be applied to lymphology? What happens when science meets a know-it-all attitude? “Research” on the internet. It is striking, as hardly any lymphological disease has received as much attention and excitement in the last 25 years as the “lipoedema” disease pattern known since the 1940s. What is the reason for this new great passion; research only cared about this fat distribution disorder in the 1990s. The perspectives of our authors and other lymphological specialists are now far from a know-it-all attitude. The proper perspectives in terra incognita: What future options can I expect in lymphology?