So far, there are no confirmed reciprocal relationships between lymphovascular diseases and fungal infections of the skin and toenails. The lymphologist should be familiar with the essential diagnostic and therapeutic options in order to act curatively and preventively. Cellulitis arises on the basis of lymphedema. The sanitation of the entry points is, in addition to the specific therapy of erysipelas by germ eradication and edema management, an essential component of the treatment and a building block of recurrence prevention. The nail apparatus of the big toes is the usual site of infection with Tinea unguium. On the foot, the lateral third and fourth interdigital spaces are usually affected by whitish swollen (“macerated”) horn with only slight weeping, but significant itching. In everyday lymphological practice, the lymphologist should be familiar with the clinical picture of a filamentous or budding fungal infection of the body mantle to meet the demands of personal aesthetics and environmental hygiene. On the other hand, skin barrier disorders, which can serve as entry points for bacteria, especially Streptococci (erysipelas), must also be eliminated. Pre-therapeutic fungal identification is essential, and the selection of the appropriate antifungal and often necessary accompanying measures are further reasons to leave the elimination of the skin lesion(s) and the fungal sanitation to the dermatologist.