Lipohyperplasia dolorosa (LiDo), colloquially known as “lipoedema”, is not oedema, lymphoedema, or obesity. Apart from a negligible proportion of men, only women suffer from this lymphological disease, which has two main characteristics—fat distribution disorder in the extremities and pain. The often dramatic suffering of the patients, its manifestation, and weighting are different, and they are misunderstood by those not affected by LiDo. Therefore, as a lymphologist, please bear in mind: Listen to your patient attentively and comprehensively, listen between the lines. Your patient may be more severely affected in terms of quality of life than may be clinically evident. For these patients, the quote from Allen and Hines often still applies: “It ruined her life”. Pain is the cardinal symptom of lipohyperplasia dolorosa in the arms and legs. LiDo patients are often dissatisfied and frustrated. Therefore, please inform them: “You are not to blame for your disease; you have done nothing wrong”. There is no evidence for an initial psychological cause, but everything points to a biological, lymph-triggered, oedematous cause of pain and discomfort. A diagnosis can be made quickly and impressively with simple means, and the surgical therapy “Lymphological Liposculpture”, known since 1997, can effectively end the disastrous fact that the disease often remains unrecognised.