Carcinomas of the oral, maxillofacial, and ENT areas are often detected too late, metastasize early via lymphatic routes, and must be treated radically through surgery and radiation. These therapies cause significant lymphedema, the treatment of which is challenging for the patient, doctor, and therapist. The effects on the psyche are more severe with lymphedema of the head than with any other edema. However, there is disagreement as to when the specific modified CDT (compression and tape must be applied complementarily) should be used. The case report explains the conditions: Manual lymphatic drainage must take into account topographical peculiarities; detailed knowledge of the lymph node levels is essential for the lymph therapist. For edemas in the head-neck area, the early start of MLD without “standing circles” during radiation seems ideal. Contraindications must be observed; cooling of the irradiated areas and application of a lymph tape additionally help effectively.