Aging Trajectories and Phenotypes

Aging is a physiological process in which changes appear progressively over time, causing the deterioration of organic systems. It is a multifaceted process determined not only by genetic and biological pathways but also by extrinsic factors whose effect can be negative, neutral, or positive. Different trajectories of aging can be described according to the impact of extrinsic factors. Anyway, aging implies the progressive reduction of physiologic reserves that can bring to a vulnerable condition. Various phenotypes of age can be described according to the literature. The identification of phenotypes is worthwhile for an appropriate approach to older patients with the aim of providing patient-tailored treatments and care.