The optimal distance from the pylorus where resection should start has been a topic of discussion. Earlier recommendations have largely been opinion-based. However, more recently, the focus has been on the resection of a larger portion of the antrum. In the current chapter, we present 22 studies and three meta-analyses comparing closer resection to the pylorus with standard resection sparing a larger portion of the antrum. Antrum resection was associated with greater postoperative weight loss at 1 and 2 years after surgery, but at the cost of a slight increase in the risk for postoperative complications, mainly nausea, vomiting, and reflux, during the first months after surgery. Thus, resection of the antrum can be safely started at a distance of 2–4 cm from the pylorus. Future studies are needed to evaluate the effects and risks over a follow-up time extending beyond 2 years after surgery and to ensure less subjective measurements of the remaining antrum.