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In this chapter we will consider how the cell can maintain its internal environment despite differences in concentration of ions and other charged species both inside and outside of the cell membrane. We outline the principles of concentration balance, electrical neutrality and Gibbs-Donnan equilibrium and how to apply them to a model of a cell. We then see how to calculate equilibrium potentials for individual ions as well as the membrane potential and understand why these are not always the same value.

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Cellular Homeostasis and Membrane Potential

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  • 发表日期：

    2025年

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  • Michael Chappell,
  • Stephen Payne

摘要

In this chapter we will consider how the cell can maintain its internal environment despite differences in concentration of ions and other charged species both inside and outside of the cell membrane. We outline the principles of concentration balance, electrical neutrality and Gibbs-Donnan equilibrium and how to apply them to a model of a cell. We then see how to calculate equilibrium potentials for individual ions as well as the membrane potential and understand why these are not always the same value.