Predicting students’ academic performance during online learning has been considered a major task during the pandemic period. During the online mode of learning, academic activities have been affected in such a way that the management of educational institutions has planned to design support systems for predicting the students’ performance to reduce the dropout ratio of the students and bring improvement in academic activities. During COVID-19, the main challenge is maintaining students’ grades by predicting their academic performance using different techniques such as Education Data Mining and Learning Analytics. Different features have been identified related to the teaching mechanisms in online learning, which have a great impact on the improvement of academic performance. A high-quality dataset helps us to generate productive results, which in turn helps us to make effective decisions for promoting high-quality education. In this research, we have proposed five prediction models for predicting academic performance by collecting an imbalanced dataset of 350 students with the same computer science domain. After applying pre-processing techniques for cleaning the data, we have applied the machine learning models, including K-Nearest Neighbor Classifier, Decision Tree, Random Forest, Support Vector Classifier, and Gaussian Naive Bayes. We have predicted the results for an imbalanced, balanced dataset after feature selection. Support Vector classifier has produced the best results in a balanced dataset with selected features by giving an accuracy of 96.89%.