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Transcranial direct current stimulation (tDCS) is a potentially effective intervention for stroke rehabilitation. However, conventional tDCS is limited by spatial resolution to specifically target a brain region. Therefore, this study utilized TMS, and computational modeling-guided high-definition tDCS (HD-tDCS). Stroke participants had three visits 1) anodal HD-tDCS stimulation of the primary motor cortex to improve function of the corticospinal tract in the lesioned hemisphere, 2) cathodal stimulation of the dorsal premotor cortex to inhibit use of the cortico-reticulospinal tract in the contralesional hemisphere, and 3) sham. The effect was assessed by qualitative EEG metrics Delta-Alpha Ratio (DAR) and Delta-Theta-Alpha-Beta Ratio (DTABR) as objective outcome measures. Both anodal and cathodal stimulations significantly decreased the DAR and improved Fugl-Meyer Upper Extremity scores. No significant changes in DTABR. Targeted HD-tDCS may improve brain function and reduce post-stroke impairments which could be integrated with robotic based therapy as future work. DAR could be an objective method to assess alteration of brain activity in stroke rehabilitation.

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Targeted Brain Stimulation Alters Resting State EEG and Reduces Post-stroke Impairment

  • 会议论文

  • 发表日期：

    2025年

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  • Jordan N. Williamson,
  • Beni E. Mulyana,
  • Rita Huan-Ting Peng,
  • Dorothy He,
  • Shirley A. James,
  • Evgeny V. Sidorov,
  • Yuan Yang

摘要

Transcranial direct current stimulation (tDCS) is a potentially effective intervention for stroke rehabilitation. However, conventional tDCS is limited by spatial resolution to specifically target a brain region. Therefore, this study utilized TMS, and computational modeling-guided high-definition tDCS (HD-tDCS). Stroke participants had three visits 1) anodal HD-tDCS stimulation of the primary motor cortex to improve function of the corticospinal tract in the lesioned hemisphere, 2) cathodal stimulation of the dorsal premotor cortex to inhibit use of the cortico-reticulospinal tract in the contralesional hemisphere, and 3) sham. The effect was assessed by qualitative EEG metrics Delta-Alpha Ratio (DAR) and Delta-Theta-Alpha-Beta Ratio (DTABR) as objective outcome measures. Both anodal and cathodal stimulations significantly decreased the DAR and improved Fugl-Meyer Upper Extremity scores. No significant changes in DTABR. Targeted HD-tDCS may improve brain function and reduce post-stroke impairments which could be integrated with robotic based therapy as future work. DAR could be an objective method to assess alteration of brain activity in stroke rehabilitation.