Engineers, neuroscientists, neurosurgeons, orthopedists and physiotherapists strive to develop and optimize bidirectional neural interfaces for patients wearing artificial limbs. Despite substantial progress made in the last decades, the sensory feedback delivered to patients remains only near-natural and difficult to convey. We believe that incorporating knowledge on neural control of movement may facilitate the design of novel bionic limbs. Identifying neuromuscular adaptations after limb amputation and characterizing their motor control response toward a bionic limb may be of great benefit. Here we review and comment on the opportunity to integrate these important aspects to minimize uncertainties while developing the next generation of bionic limbs.