In modern educational settings, the integration of educational games and responsible Artificial Intelligence (AI) presents a promising avenue for developing digital skills and soft skills such as problem-solving, multidisciplinarity, interdisciplinarity, collaborativity, critical thinking, and ethics among learners, required for success in the 21st century. This chapter provides an overview of the intersection between these elements, exploring the synergistic relationship between prosocial educational games, AI technologies, including Intelligent Tutoring Systems (ITSs) and student modeling for personalization and adaptivity, and the cultivation of these important skills. Additionally, it examines the role of prosocial games in fostering empathy, teamwork, and other positive social behaviors. Beginning with an examination of the evolution of educational games and AI in education, the chapter examines the various ways in which these technologies can enhance learning experiences and promote skill development. Furthermore, it explores the ethical considerations and challenges associated with the integration of AI in educational games, emphasizing the importance of responsible AI design and implementation, including adherence to GDPR regulations for data protection. Through case studies and examples, this chapter illustrates the potential benefits and limitations of leveraging AI-powered educational games to develop digital skills and soft skills. It also discusses how fuzzy logic constitutes a transparent AI technology that can enhance the educational experience. By providing insights into the transformative role of educational games with responsible AI, this chapter aims to inform educators, researchers, and policymakers about the opportunities and considerations in harnessing these technologies to develop essential skills for the 21st century.