This chapter explores the critical role of neuromuscular conditioning in musculoskeletal (MSK) medicine, focusing on principles and practices that enhance muscle strength, stability, and overall functional capacity. It begins by emphasising the importance of prioritising strength and weight over repetitions in training, to optimise muscle hypertrophy, joint stability, and neuromuscular control. The chapter then examines the interplay between cardiovascular (CV) and MSK health, demonstrating the necessity of integrating both elements into comprehensive training and rehabilitation programmes. Advanced techniques, such as Neuromuscular Electrical Stimulation (NMES) and Blood Flow Restriction (BFR) training, are presented as innovative methods to build strength with minimal joint strain, particularly valuable in prehabilitation and postoperative recovery contexts. Additionally, the chapter addresses the significance of enhancing gait, coordination, and movement, underscoring their importance in injury prevention and recovery. By integrating these strategies, the chapter provides a comprehensive guide to improving MSK health through targeted neuromuscular conditioning, offering insights into optimising patient outcomes.