The meniscus and cartilage are essential components of the knee joint, responsible for load-bearing, shock absorption, and joint stability. Injuries to these tissues, caused by trauma or degeneration, are common and significantly increase the risk of osteoarthritis. Current treatments, including meniscectomy and cartilage debridement, provide symptom relief but fail to restore the natural structure and function of the tissues, leading to suboptimal long-term outcomes. Regenerative medicine offers promising alternatives, utilising techniques such as stem cell therapy, platelet-rich plasma (PRP), gene therapy, and biomaterials to promote tissue repair and regeneration. Despite significant advancements, challenges remain, including immunological responses, limited tissue integration, and maturation of regenerated structures. Combining regenerative techniques holds promise for synergistic effects and improved clinical outcomes. Regenerative strategies have the potential to revolutionise treatment for meniscus and cartilage injuries by restoring functionality at a cellular level, offering durable solutions and reducing the progression of osteoarthritis. However, further research and innovation are essential to overcome current barriers and achieve widespread clinical application.