The concentration of specific industries in relatively small areas exists in many countries. This characteristic incentivizes cooperation and facilitates the optimal use of common resources. That is the case of the cluster of crop and chemical manufacturing industries in the center of Argentina, next to the Parana River. All of these plants are closely linked to the use of water streams in associated processes. The objective of this work is to minimize the overall costs of water and energy consumption through the optimal design of an inter-plant pipeline network. This is achieved by considering the daily availability and demand of hot water at each node over time, while ensuring that all pipelines are capable of reversing flows, if needed, at the expense of specific equipment and operating costs. The optimization model developed in this work can be categorized as a MILP formulation that considers fluid dynamics variables, temperatures, energy and flow in order to properly determine the pipeline diameters. The construction and operation of water pipelines in concentrated industrial regions can leverage positive impacts on the sustainable use of natural resources. In contrast to previous contributions, explicit consideration of flow reversals offers benefits that can significantly reduce investment costs.