Industry 4.0 raises concerns about the inclusion of low-income people. Researchers approach entrepreneurship as a path to social inclusion. In this context, this paper aims to investigate how Industry 4.0 engages low-income people under the perspective of entrepreneurship. This paper is based on a systematic literature review using bibliometrics and content analysis. The paper combines RStudio, VOSviewer and NVivo software analysis for conducting a systematic literature review. The paper also conducted a content analysis. This study understands that entrepreneurship has different challenges in Industry 4.0 depending on the social group. To better understand these challenges, low-income people were divided into three social groups: low-literacy and poor people, rural communities and women. The results indicated that the main challenges to engage low-income people on Industry 4.0 are digital inclusion, digital financial inclusion, adoption of digital platforms, and others.