Laryngeal cancer is the most prevalent form of malignancy in the head and neck region. Squamous cell carcinomas make up the majority of laryngeal tumors, accounting for about 95% of cases, and primarily affect the glottis or supraglottis. The division of the larynx into these specific parts is important due to their distinct embryological development and lymphatic drainage patterns. The main risk factors for laryngeal cancer are smoking and heavy alcohol consumption, and the combination of these factors significantly increases the likelihood of developing the disease. The symptoms experienced by patients depend on the location of the tumor. Glottic cancer typically presents with hoarseness, while supraglottic neoplasms often do not cause early symptoms and may be discovered when a neck lump is noticed. Endoscopy is the preferred clinical assessment method for identifying laryngeal growths. Once a diagnosis is confirmed through histopathological examination, staging is necessary to determine the appropriate treatment approach. Early-stage laryngeal cancer (stages I and II) can often be treated with a single form of therapy, whereas advanced cases (stages III and IV) may require multiple modalities to achieve a curative response. The prognosis for early-stage cancer is generally favorable, but recurrences may necessitate salvage total laryngectomy, which can significantly impact the quality of life.

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Laryngeal Cancer

  • Alexandros Poutoglidis,
  • Evropi Forozidou

摘要

Laryngeal cancer is the most prevalent form of malignancy in the head and neck region. Squamous cell carcinomas make up the majority of laryngeal tumors, accounting for about 95% of cases, and primarily affect the glottis or supraglottis. The division of the larynx into these specific parts is important due to their distinct embryological development and lymphatic drainage patterns. The main risk factors for laryngeal cancer are smoking and heavy alcohol consumption, and the combination of these factors significantly increases the likelihood of developing the disease. The symptoms experienced by patients depend on the location of the tumor. Glottic cancer typically presents with hoarseness, while supraglottic neoplasms often do not cause early symptoms and may be discovered when a neck lump is noticed. Endoscopy is the preferred clinical assessment method for identifying laryngeal growths. Once a diagnosis is confirmed through histopathological examination, staging is necessary to determine the appropriate treatment approach. Early-stage laryngeal cancer (stages I and II) can often be treated with a single form of therapy, whereas advanced cases (stages III and IV) may require multiple modalities to achieve a curative response. The prognosis for early-stage cancer is generally favorable, but recurrences may necessitate salvage total laryngectomy, which can significantly impact the quality of life.