Thyroglossal duct cyst (TGDC) is the most commonly encountered mass in the midline anterior neck, often found in the perihyoid area. TGDC represents approximately 75% of all congenital neck masses and typically occurs in children and young adults. TGDCs originate from persistent epithelial remnants of the thyroglossal duct, a structure that guides the descent of the thyroid gland from the foramen caecum to its final position in the anterior neck during embryogenesis. If TGDC remnants persist, they may give rise to cysts or fistula later in life. It is classically described as a painless anterior neck swelling that moves with deglutition and tongue protrusion. Most TGDCs are asymptomatic. Infection and sinus formation are the most common complications of thyroglossal duct cysts. While clinical examination is often sufficient for diagnosing a TGDC, in most cases, imaging such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) is required to identify a normal thyroid gland, appreciate the characteristics of the cyst, and rule out other conditions such as dermoid/epidermoid cysts, ectopic thyroid gland, lymphadenopathy, branchial cleft cysts, ranula, and cystic hygromas. Surgical excision of TGDC with the Sistrunk procedure is the gold standard of treatment.