Hulusi Behçet’s medical life as a clinician, master, and researcher is actually a wholly success story. His most well-known and probably the most important professional achievement is the definition of Behçet’s disease. Due to the honor of being named after a Turkish physician, Hulusi Behçet, Behçet’s disease has a special significance for Türkiye and the Turkish medical community. Behçet’s disease continues to be a current issue in the medical world, with various aspects spanning from past to present. In this chapter, influential perspectives of Hulusi Behçet’s personal and professional life and the chronology of the definition of Behçet’s disease are narrated.