This book chapter offers a thorough examination of fluoride toxicity, exploring the potential health risks and consequences for human well-being. While fluoride is a naturally occurring mineral known for its dental health benefits, concerns have arisen regarding the negative impacts of excessive fluoride exposure on overall health. Drawing upon extensive literature, this chapter delves into the intricate mechanisms through which fluoride toxicity influences various physiological processes and organ systems. It critically evaluates studies pinpointing the adverse effects of fluoride on cellular function, underscoring the multifaceted nature of fluoride toxicity. Moreover, the chapter delves into the array of health risks linked to fluoride toxicity, encompassing dental and skeletal fluorosis, neurotoxicity, endocrine disturbances, and potential carcinogenic properties. By synthesizing evidence across scientific domains, it aims to provide a holistic understanding of the intricate interplay between fluoride exposure and human health outcomes. Ultimately, this chapter endeavors to heighten awareness regarding the necessity of monitoring environmental fluoride levels and evaluating the associated health risks of fluoride toxicity. By elucidating the current knowledge landscape on this pressing issue, it aims to shape public health policies and advocate for strategies to mitigate the detrimental effects of fluoride exposure.