Screening Children at Risk for Retinoblastoma

A panel of members of the American Association of Ophthalmic Oncologists and Pathologists. (AAOOP) with support of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) and the American Academy of Pediatrics (AAP) was convened. The consensus statement from the panel recommended dedicated ophthalmic screening for all children at risk for retinoblastoma above the population risk. Risk stratification, including genetic testing and counseling, serves as the basis for screening children at elevated risk for the development of retinoblastoma. The frequency of examinations is adjusted by the expected risk for RB1 mutation. Examination schedules are stratified based on high-, intermediate-, and low-risk children. Children at high risk for retinoblastoma require more frequent screening, which may preferentially be examinations under anesthesia.