This paper presents a comprehensive study of a blockchain-based pharmaceutical supply chain management system utilizing Non-Fungible Tokens (NFTs) and smart contracts. The research addresses the ongoing challenges in maintaining transparency, ethical sourcing, and supply chain integrity within the pharmaceutical industry. We propose a system that integrates blockchain technology with NFTs to enhance traceability and data integrity throughout the supply chain process. The performance and adaptability of the proposed system are evaluated across four EVM-compatible platforms: Binance Smart Chain, Polygon, Fantom, and Celo. Key operations such as data logging, NFT generation, and NFT transferability are examined, providing insights into the system’s efficiency, speed, and reliability. An economic assessment comparing transaction fees across these platforms is also presented. The study contributes to the ongoing efforts to improve pharmaceutical supply chain integrity and offers a potential solution to address the specific challenges faced by the industry.