Cyber-physical systems (CPSs) are the essential element in the implementation of Industry 4.0. These systems are catalysed by pooling physical and topological components. Computer vision-based artificial intelligence models in CPSs enable innovative applications in smart manufacturing, transport, and agriculture. Computer vision technology and Artificial Intelligence are applied to monitor and analyse CPS’s operation process and status to achieve operational excellence through productivity improvement and energy optimisation. This paper proposes the system architecture of the Artificial Intelligence Cyber-Physical System Platform for Smart Manufacturing Systems. The system architecture integrates computational algorithms, communication networks, and physical processes. A CPS in the smart factory involves the integration of a mechatronic device with a control system and networked systems for advanced control, monitoring, and interaction. The proposed platform implementation approach provides a versatile and dynamic solution for CPS in the manufacturing industry. This paper presents the motivation, status, and implementation of the Instrumentation and Measurement of a CPS for Industry 4.0 using an AI Cyber-Physical System Platform.