Soft tissue tumours are rare, and sarcomas account for less than 1% of all malignancies. Since many different soft tissue tumours exist with overlapping clinicopathological features, diagnostic decision-making can be challenging. Diagnosis relies upon a complex and integrated combination of clinical features (age, gender, site and size of tumour, hereditary context), imaging studies (superficial or deep-located, primary soft tissue or bone, including epiphysis, metaphysis, or diaphysis) [1], microscopic morphology (with representative biopsy material), immunohistochemistry, and molecular genetics [2]. When these prerequisites of appropriate clinical practice and radiology are met, the histopathological classification process begins [3].

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Histopathologic Challenges in the Diagnostic Stage

  • A. H. G. Cleven,
  • P. C. W. Hogendoorn

摘要

Soft tissue tumours are rare, and sarcomas account for less than 1% of all malignancies. Since many different soft tissue tumours exist with overlapping clinicopathological features, diagnostic decision-making can be challenging. Diagnosis relies upon a complex and integrated combination of clinical features (age, gender, site and size of tumour, hereditary context), imaging studies (superficial or deep-located, primary soft tissue or bone, including epiphysis, metaphysis, or diaphysis) [1], microscopic morphology (with representative biopsy material), immunohistochemistry, and molecular genetics [2]. When these prerequisites of appropriate clinical practice and radiology are met, the histopathological classification process begins [3].